Upregulatory Effects of Nobiletin, a Citrus Flavonoid with Anti-dementia Activity, on the Gene Expression of mAChR, ChAT, and CBP
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چکیده
Upregulatory Effects of Nobiletin, a Citrus Flavonoid with Anti-dementia Activity, on the Gene Expression of mAChR, ChAT, and CBP Junko Kimura1, Kosuke Shimizu1, Jiro Takito2, Kiyomitsu Nemoto3, Masakuni Degawa3, Akihito Yokosuka4, Yoshihiro Mimaki4, Naoto Oku1, Yasushi Ohizumi1,5 1 Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan 2 Department of Oral Anatomy and Developmental Biology, School of Dentistry, Showa University, Tokyo, Japan 3 Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan 4 Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan 5 Kansei Fukushi Research Institute, Tohoku Fukushi University, Sendai, Japan
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Anti-dementia Activity of Nobiletin, a Citrus Flavonoid: A Review of Animal Studies
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Medicinal plants contain pharmacological substances including flavonoids, and their extracts have been therapeutically administered for cancer therapy in vitro and in vivo. We investigated the efficacy of a polymethoxy flavonoid, nobiletin, from Citrus depressa on tumor invasion in vitro. Nobiletin inhibited the tumor-invasive activity of human fibrosarcoma HT-1080 cells in the Matrigel model, ...
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Medicinal plants contain pharmacological substances including flavonoids, and their extracts have been therapeutically administered for cancer therapy in vitro and in vivo. We investigated the efficacy of a polymethoxy flavonoid, nobiletin, from Citrus depressa on tumor invasion in vitro. Nobiletin inhibited the tumor-invasive activity of human fibrosarcoma HT-1080 cells in the Matrigel model, ...
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